Optimisation of time-scheduled regimen for anti-cancer drug infusion

Optimisation of Time-scheduled Regimen for Anti-cancer Drug Infusion

The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. The object of the present paper is to investigate mathematically and numerically optimal strategies in cancer chronotherapy. To this end a mathematical model describing the time evolution of efficiency and toxicit...

Fabrication and evaluation of gelatin nanoparticles for delivering of anti - cancer drug

The aim of present study was to prepare gelatin nanoparticle for drug and gene delivery applications. These nanoparticles were prepared by two-step desolvation method. The body distribution of colloidal drug delivery systems was mainly influenced by two physicochemical properties namely particle size and surface characteristics. The influence of several factors on the fabrication process includ...

Delay-Scheduled Controllers for Inter-Area Oscillations Considering Time Delays

Unlike the existing views that was introduced the existence of delay caused by the transmission of wide area measurement system data (WAMS) into the controllers input of the power oscilation damping (POD) by communication networks as a reason for poor performance of the POD controllers. This paper shows that the presence of time delay in the feedback loop may improve the performance of a POD co...

new drug regimen for tuberculosis

MOGA-Based Multi-drug Optimisation for Cancer Chemotherapy

This paper presents a novel method of multi-drug scheduling using multi-objective genetic algorithm (MOGA) that can find suitable/optimum dosages by trading-off between cell killing and toxic side-effects of chemotherapy treatment. A close-loop control method, namely Integral-Proportional-Derivative (I-PD) is designed to control dosages of drugs to be infused to the patient’s body and MOGA is u...